PEPTIDESTAT
ApprovedWeight lossSubcutaneousEvidence 5/5

Tirzepatide

Also known as: LY3298176, Mounjaro, Zepbound

Activates GLP-1 and GIP receptors to improve glycemic control and reduce appetite + body weight.

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Tirzepatide
Drug class
Dual agonist (GLP-1 / GIP)
Primary targets
GLP-1R, GIPR
Dose reference
2.5–15 mg once weekly
Half-life
~5 days
Developer / origin
Eli Lilly
Reference year
2022
Evidence score
5/5 - Approved with large human trials

Approved uses

  • Type 2 diabetes
  • Chronic weight management
Evidence 5/5

Approved with large human trials

Tirzepatide has large randomized obesity and diabetes trials plus FDA-regulated labeling for approved indications.

Approved medication with substantial human clinical evidence.

Evidence basis

  • Large human RCTs
  • FDA-regulated labeling
  • Approved for type 2 diabetes and chronic weight management

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

Tirzepatide guides

Read the matching guide or adjacent research pages for more context.

What Is GLP-1? Complete Guide to the Hormone, the Drugs, and What They DoGLP-1 is a hormone your gut releases after eating. GLP-1 agonist drugs amplify its effect — slowing digestion, reducing appetite and improving blood sugar. This is the complete guide.Best GLP-1 for Weight Loss in 2026: Honest Head-to-HeadZepbound currently leads on average weight loss in trials. Wegovy has the best cardiovascular evidence. Here's the honest head-to-head of every approved GLP-1 for weight loss.GLP-1 for Weight Loss: The 2026 Complete GuideGLP-1 weight-loss drugs produce 8–21% average body-weight reduction in trials. Here's how to think about them honestly — eligibility, results, cost, side effects, and what happens when you stop.Retatrutide: What the Research Actually ShowsRetatrutide is an investigational triple-agonist peptide drawing major attention for weight loss. Here's what the clinical research actually shows.

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Activates GLP-1, GIP and glucagon receptors simultaneously to suppress appetite and raise energy expenditure.

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Semaglutide

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Mimics the incretin GLP-1, slowing gastric emptying and reducing appetite while improving insulin secretion.

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Liraglutide

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Daily GLP-1 analog. Reduces appetite and improves glycemic control via the same incretin pathway as semaglutide.

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Weight lossInvestigational

Long-acting amylin analog that slows gastric emptying and reinforces satiety; studied in combination with semaglutide (CagriSema).

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Weight Loss Peptides

Compare weight loss peptides including GLP-1, GIP, amylin and triple-agonist compounds by approval status, mechanism, half-life and evidence score.

Research & educational purposes only

The information on PeptideStat is for educational and research purposes only and is not medical advice. Many peptides discussed are research compounds not approved for human use. Always consult a qualified healthcare professional before making any health decisions. Articles may contain affiliate links — we may earn a commission at no extra cost to you.