Research onlyCognitiveIntranasalEvidence 2/5

Semax

Also known as: ACTH(4-10) analog

Heptapeptide derived from ACTH(4-10). Russian neuropeptide studied for nootropic and neuroprotective effects, partly via BDNF upregulation.

Semax product image
Drug class
Synthetic ACTH analog
Primary targets
Melanocortin / BDNF pathways
Dose reference
200–600 mcg per dose (intranasal, research)
Half-life
Minutes
Developer / origin
Russian Academy of Sciences
Reference year
1982
Evidence score
2/5 - Mostly preclinical neuroprotection evidence
Evidence 2/5

Mostly preclinical neuroprotection evidence

Semax has preclinical neuroprotection literature and regional clinical history, but limited independently validated human evidence for consumer cognitive use.

Mostly animal, ex vivo, cell, or indirect evidence.

Evidence basis

  • Animal neuroprotection models
  • Regional clinical history
  • Limited independent human evidence

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

Compare with related peptides

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3/5
CognitiveResearch only

Russian-developed analog of tuftsin marketed (in Russia) as an anxiolytic. Mechanism involves modulation of GABA and stress-response pathways.

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